Chinese Doctors Share Playbook For Treating Severe COVID-19

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ECMO machine -MedPage Today

Health Editor’s Note: Warning: There are  medical terms in the following article. I have furnished definitions for the less medically inclined. Chinese doctors have shared information for treating COVID-19 patients with the United States. The Chinese playbook has proved to be best practice in treating patients with COVID-19. China has already been through what the U.S. is experiencing now. Definitions follow: 

  • extracorporeal membrane oxygenation (ECMO)-an advanced life support technique used for patients with life-threatening heart/and or lung problems which provides long term heart support and breathing and is used when all other treatments have been tried.
  • hypoxemia- low level of oxygen in the blood
  • hyperlipidemia- high level of fats in the blood
  • echocardiography-test that uses ultrasound to show how your heart muscle and valves are working
  • intubation- inserting a tube, called an endotracheal tube (ET), through the mouth and then into the airway. This is done so that a patient can be placed on a ventilator to assist with breathing during anesthesia, sedation, or severe illness. The tube is then connected to a ventilator, which pushes air into the lungs to deliver a breath to the patient…..Carol 

Chinese Doctors Share the Playbook for Severe COVID-19

by Nicole Lou, Staff Writer, MedPage Today

Better to start extracorporeal membrane oxygenation (ECMO) sooner rather than later, and hold back on sending older physicians into the wards — these were among the lessons shared by Chinese doctors treating severe cases of COVID-19 during a Thursday webinar sponsored by the American College of Cardiology.

The case of a 31-year-old male Wuhan resident illustrated just how easily COVID-19 can progress to multi-organ dysfunction, according to Chinese doctors who arrived in Wuhan 6 weeks ago to help combat the pandemic.

The patient had complained of 3 weeks of intermittent fever and coughing when he tested positive for the novel coronavirus. Medications he was given in the hospital included treatments for his diabetes and hyperlipidemia, as well as 6 days of Arbidol, an antiviral not available in the U.S.

Nevertheless, the patient’s condition deteriorated as he developed acute heart failure, sepsis, and liver dysfunction. Infection and inflammation biomarkers were very high, the doctors noted.

The staff continued to treat him with everything they had, however, paying attention to him and keeping him hydrated. In the end, he recovered.

Success stories like this one are coming out of China just after the country announced the first day that it found no new COVID-19 cases within its borders.

For one, some critically severe patients will still have severe hypoxemia on ventilation and will require ECMO, according to Ning Zhou, MD, PhD, who is currently working in the ICU ward of Tongji Hospital in Wuhan.

The typical ECMO case looks something like this: a man age 50, with 11 days of fever, shortness of breath for 2 days, oxygen saturation of 75%, reduced lymphocyte levels, high NT-proBNP and cardiac troponin I, and ejection fraction 45% on echocardiography. He does not improve on antibacterial, antiviral therapy, but in fact shows hypoxemia getting worse and is sent to the ICU.

Zhou said he has performed five ECMO cases (four recovered, one ongoing) and it’s been administered for an average 9.2 days per patient. He recommended that hospital staff employ veno-venous ECMO before trying veno-arterial ECMO.

Importantly, he said, ECMO doesn’t help people who are dying, and should be offered earlier, before they get to that point.

“Don’t wait. You lose the opportunity, especially for those young patients. ECMO is not for prolonging life for days. It’s an opportunity for patients to survive,” he emphasized.

People who are less likely to be helped by ECMO include those with irreversible severe brain injury and people over 70 years old, Zhou suggested.

“In China, we don’t have so many ECMO systems, resources for all the patients. We have to choose who can probably recover from COVID-19,” he said.

Finally, the doctor suggested that it is time to rethink the way patients are intubated before they are given ECMO.

“How about we use ECMO first, or even use ECMO without intubation? This means we can use ECMO to support the lungs without infecting the intubation and ventilation,” he said. “We already finished three cases … We removed the intubation first and continued ECMO for supply of oxygen.”

This last suggestion was met with some hesitance from the other doctors. One said he still believed intubation should be performed before ECMO.

Unanimously dismissed by the group, on the other hand, was the idea of bringing in the Impella ventricular assist device to replace some of the heart’s function.

This is nearly impossible in the ICU as the device needs to be implanted in the cath lab, the session moderator noted. Furthermore, operators are being told to wear three or four gloves and therefore lose some sense of touch, making this an extremely difficult implant procedure in present circumstances.

Needless to say, hospital staff are advised to wear full personal protective equipment at all times.

Harlan Krumholz, MD, of Yale University and Yale New Haven Hospital in Connecticut, asked during the virtual meeting whether risk factors for poor COVID-19 prognosis might be identified from an international pooling of data.

The Chinese doctors replied that it is very hard to predict individual patients’ outcomes. Some patients can appear to be on the recovery but worsen suddenly.

However, men do appear more susceptible to infection, they offered — Zhou disclosed that of the 30 beds in his ICU ward, more than 20 are filled by men.

The speakers, all men, said that in China, doctors over age 60 are prohibited from going to the front lines. Only junior physicians are allowed to take care of COVID-19 patients.

Biography
Carol graduated from Riverside White Cross School of Nursing in Columbus, Ohio and received her diploma as a registered nurse. She attended Bowling Green State University where she received a Bachelor of Arts Degree in History and Literature. She attended the University of Toledo, College of Nursing, and received a Master’s of Nursing Science Degree as an Educator.

She has traveled extensively, is a photographer, and writes on medical issues. Carol has three children RJ, Katherine, and Stephen – two daughters-in-law; Suzy and Katie – two granddaughters; Isabella Marianna and Zoe Olivia – and one grandson, Alexander Paul. She also shares her life with husband Gordon Duff, many cats, and two rescue pups.

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6 COMMENTS

  1. I saw a post this on instagram – no reference to source –
    Doctors in India have been successful in treating Coronavirus with a combination of drugs: Lopinavir, Retonovir, Oseltamivir along with Chlorophenamine and will be suggesting this combined drug treatment globally.
    Researchers at the Erasmus Medical Center claim to have found an antibody against CV-19.
    And than there is this, as mentioned in other articles the anti malaria drug chloroquine which “Should have been a Doctor” Donald has called a cure.
    There seems to be some rapid advances on this virus hopefully the tide can be turned as it appears the cases outside of China are set to blow up. And China has closed it’s last coronavirus hospital