Health Editor’s Note: Connecting the dots for COVID-19. Could this mean that some of the parts of the COVID-19 puzzle are becoming apparent? Are we closer to understanding why some people are hit harder with COVID-19 than others?
On March 23, VT brought you the news of how the use of chloroquine for COVID-19 treatment could harm a percentage of the world population who have G6PD deficiency. This is a This deficiency, brought on by a genetic condition, is commonly found in the Mediterranean region, Africa, and Asia. People in Spain and Italy have been more affected than other some other countries. In the U.S., the African-American population is being harder hit. Could this be the genetic condition that causes a difference in the severity of a COVID-19 infection?…..Carol
Does G6PD Deficiency Relate to COVID-19 Infection?
In an April 8 MedPage Today article, Mark Zucker, MD, asked the question as to why there is differential susceptibility to COVID-19 infection. In other words, why do some people become severely ill while others are asymptomatic? He raised the issue of possible genetic determinants in susceptibility and response to the coronavirus.
This is a question that I have been pondering as well, particularly as to whether there may be a link between glucose-6-phosphate dehydrogenase (G6PD) deficiency and susceptibility to, and virulence of, COVID-19 infection. G6PD deficiency is a common, X-linked recessive genetic condition that affects some 400 million people worldwide. It is the most common human enzyme defect. G6PD is an important catalyst in the pentose phosphate pathway, in which glucose is converted to pentose sugars and NADPH is produced. NADPH serves an important role in ridding cells of free oxygen radicals, thereby reducing oxidative stress and preventing cell destruction. Most cells in the body contain mitochondria, which also generate NADPH. However, red blood cells lack mitochondria and, therefore, rely upon the pentose phosphate pathway for generating this important cell-protecting molecule.
Carol graduated from Riverside White Cross School of Nursing in Columbus, Ohio and received her diploma as a registered nurse. She attended Bowling Green State University where she received a Bachelor of Arts Degree in History and Literature. She attended the University of Toledo, College of Nursing, and received a Master’s of Nursing Science Degree as an Educator.
She has traveled extensively, is a photographer, and writes on medical issues. Carol has three children RJ, Katherine, and Stephen – one daughter-in-law; Katie – two granddaughters; Isabella Marianna and Zoe Olivia – and one grandson, Alexander Paul. She also shares her life with her husband Gordon Duff, many cats, and two rescues.