New Treatments for Children with COVID-Related Multisystem Inflammatory Syndrome

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Credit: CDC/ Alissa Eckert, MS; Dan Higgins, MAMS

Immunotherapy, steroids had positive outcomes in children with COVID-related multi-system inflammatory syndrome

News Room Heart News Circulation/Journal of the American Heart Association

DALLAS, May 18, 2020 — Treatment with antibodies purified from donated blood – immune globulin therapy – and steroids restored heart function in the majority of  children with COVID-related multisystem inflammatory syndrome, according to new research published yesterday in Circulation, the flagship journal of the American Heart Association.

Physicians around the world have recently noted that a small number of children exposed to  COVID-19 have an emerging condition with features overlapping toxic shock syndrome and similar to a heart condition known as Kawasaki disease, together with cardiac inflammation. The symptoms most commonly observed are high-spiking fever, unusual lethargy over several days (asthenia), digestive signs including severe abdominal pain, vomiting or diarrhea, swollen lymph nodes (adenopathy) and skin rash.

In this small study, “Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic,” researchers in France and Switzerland retrospectively collected and analyzed clinical, biological, therapeutic and early outcome data for children admitted to the pediatric intensive care unit from March 22 to April 30, 2020, with fever, cardiogenic shock or acute left ventricular dysfunction with inflammatory state.

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