…from Russia Today, Moscow
[ Editor’s Note: A group of us inside VT have been following the large amount of life extension research that has been going on for some time now. The testing starts out on mice first, and then moves on to human trials prior to being available for human use.
All of the earlier research using nano particles involved their delivering a cancer killing antidote to the individual cell. The obvious benefit was that the cancer killing drug would not also be spread throughout the body and create negative side effects.
This new research came from thinking outside the box, making the nanoparticle itself what killed the cancer cell, by cloaking it with an outside layer of building block material that the cancer cell needs to live and hence allows it to enter, where the nano particle then kills it.
This is the biggest advance in this science in the years I have been watching, about five now. Carol Duff has been doing most of the science reporting, as it saves the readers all the sifting time to find those studies of most interest to more people.
And then we also have a selfish motive, which is our trying to hang around past 90 if we can, so we can keep publishing VT for another 20 years 🙂 …Jim W. Dean ]
– First published … September 28, 2020 –
A new experimental treatment reportedly tricks cancer cells into self-destructing, without the use of any drugs, providing new hope for winning the war on many different types of the disease.
The treatment involves a nanoparticle coated in an amino acid called L-phenylalanine. The chemical is not naturally produced in the body but is instead absorbed from meat and dairy produce that humans consume.
L-phenylalanine is the perfect bait as it is one of the main amino acids cancer cells require to grow and spread throughout the human body, wreaking havoc in the process.
The novel new treatment has proven incredibly successful on mice. The secret is the nanoparticle Nanoscopic phenylalanine Porous Amino Acid Mimic, or Nano-pPAAM for short.
Nano-pPAAM triggers overproduction of reactive oxygen species (ROS) which causes a cascade effect inside the cancer cells, killing them while leaving surrounding, healthy cells unharmed.
“Against conventional wisdom, our approach involved using the nanomaterial as a drug instead [of] as a drug-carrier,” says material scientist Dalton Tay from Nanyang Technological University in Singapore.
The method kills roughly 80 percent of breast, skin, and gastric cancer cells in mice, on par with leading chemotherapy treatments but without the nasty side effects. Research into nanoparticles typically focuses on using them as a delivery mechanism for drugs, not as the treatment itself.
There is still a long series of regulatory hurdles to surpass before the treatment will be available for human patients, however.
If it passes muster in clinical trials it will also help combat drug-resistant, recurring forms of cancer as well, providing yet another possible beacon of hope; without drugs to fight against, the cancer won’t have anything to resist.
Jim W. Dean Archives 2009-2014