by Fabio Giuseppe Carlo Carisio for VT Europe
All Italian Links inside the article can be read in English with machine translating
First posted on July, 11,21
The onset of the Delta (Indian) and Epsilon (Californian, currently not widespread in Europe) variants developed by Covid-19 in its mutations is already raising the specter of a third dose shot as much as that of an annual booster vaccination. But it also raises doubts about the actual effectiveness of vaccines.
«The effectiveness of Moderna and Pfizer vaccines in relation to the “California” version of SARS-CoV-2, called Epsilon, decreases by 50-70%. The Epsilon coronavirus mutation found in California has learned to bypass antibodies. The research by scientists from the University of Washington and the Vir Biotechnology laboratory has been published in the journal Science (link at the bottom of the article)» reported the Russian network Sputnik.
«Experts have found three mutations in the new strain of the SARS-CoV-2 virus in critical regions of the spike protein, which the virus uses to connect with the angiotensin-converting enzyme 2 (ACE2) on the cell surface. One of these changes involved the binding zone of the coronavirus “harpoon” receptor ».
The other two mutations remodeled some of the spike protein. Thanks to these metamorphoses, the coronavirus has “learned” to neutralize the monoclonal antibodies that form after being immunized with the Pfizer and Moderna vaccines. Mutations in the new Epsilon strain likewise bypass the natural antibodies that form in humans after being infected with a coronavirus, scientists say.
SWISS-AMERICAN RESEARCH ON CALIFORNIAN VARIANT
«A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based mRNA vaccine or convalescent individuals exhibited neutralizing titers, which were reduced 2-3.5 fold against the B.1.427/B.1.429 variant relative to wildtype pseudoviruses. The L452R mutation reduced neutralizing activity of 14 out of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 out of 10 NTD-specific mAbs since the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and formation of a new disulphide bond, as revealed by mass spectrometry and structural studies».
We read in the research “SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern” published Science on July,1,2021 by Matthew McCallum and Alexandra C. Walls (with other researchers from the Department of Biochemistry, University of Washington, Seattle, USA), Jessica Bassi and Anna De Marco (with other colleagues from Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland ), Alex Chen and Maria Agostini (with other colleagues from Vir Biotechnology, San Francisco, USA) Sasha W Tilles (with other researchers from the Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, USA), together with Sonja Bernasconi Guastalla, independent physician, Giovanni Bona (with colleagues from the Clinical Research Unit, Clinica Luganese Moncucco, Lugano, Switzerland) and Christian Garzoni from the Clinic of Internal Medicine and Infectious Diseases, Luganese Moncucco Clinic, Lugano, Switzerland).
«To assess the impact of the three mutations present in the B.1.427/B.1.429 S glycoprotein on neutralization, we first compared side-by-side the neutralization potency of mRNA vaccine-elicited Abs against G614 S and B.1.427/B.1.429 S pseudoviruses. We used plasma from fifteen individuals who received two doses of Moderna mRNA-1273 vaccine and from fifteen individuals who received two doses of Pfizer/BioNtech BNT162b2 vaccine collected between 7 and 27 days after booster immunization (table S2). All vaccinees had substantial plasma neutralizing activity against G614 SARS-CoV-2 S pseudotyped viruses» explained the researchers of the Swiss and American institutes.
«These data indicate that the three B.1.427/B.1.429 S residue substitutions lead to a modest but significant reduction of neutralization potency from vaccine-elicited Abs» was the bitter conclusion of the study.
«Serum or plasma neutralizing activity is a correlate of protection against SARS-CoV-2 challenge in non-human primates and treatment with several neutralizing mAbs has reduced viral burden and decreased hospitalization and mortality in clinical trials (10, 14, 15, 22, 23, 49). The observed L452R-mediated immune evasion of B.1.427/B.1.429 S concurs with previous findings that this substitution reduced the binding or neutralizing activity of some mAbs prior to the description of the B.1.427/B.1.429 variant. The acquisition of the L452R substitution by multiple lineages across multiple continents, including the B.1.617.1 and B.1.617.2 lineages emerging in India, is suggestive of positive selection, which might result from the selective pressure of RBD-specific neutralizing Abs» reads on research.
«The SARS-CoV-2 NTD undergoes rapid antigenic drift and accumulates a larger number of mutations and deletions relative to other regions of the S glycoprotein The data herein showing immune evasion of all tested NTD-specific mAbs by the B.1.427/B.1.429 variant also support that the NTD antigenic supersite is under host immune pressure. Similar to how the S13I/W152C mutations facilitate evasion of all tested NTD-specific mAbs, E484K causes broad resistance to many RBD-specific mAbs. The independent acquisition of the E484K mutation in the B.1.351, P.1, B.1.526 variants and more recently the B.1.1.7 variant (34) suggests this could also occur in the B.1.427/B.1.429 lineages. Indeed, 4 genome sequences with the E484K RBD mutation in the B.1.427 variant have recently been deposited in GISAID. Alternatively, the S13I/W152C mutations could emerge in any of these variants. We note that the S13I mutation was recently detected in the SARS-CoV-2 B.1.526 lineage, which was originally described in New York » the scientists concluded.
THE ALARM FOR THE DELTA VARIANT
The alarm comes after the growth of the Delta variant in Italy and in the world is causing positive cases of Covid-19 to rise because it is very contagious, although it has very few symptoms, as claimed by Professor Francesco Vaia, director of the National Institute of Infectious Diseases Lazzaro Spallanzani of Rome (among the first to isolate the Italian strain of Sars-Cov-2). All of this has not only made the goal of herd immunity a utopia but has already prompted Pfizer to seek authorization for a third dose.
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This request was also rejected by the Food and Drug Administration in the USA and by the EMA (European Medicines Agency) in the European Union, probably well aware that this strategy could create even more chaos among those groups of populations skeptical about vaccines.
As this happens right after the revision of the package inserts of the Pfizer and Moderna vaccines (renamed Spikevax) with the inclusion of the danger of rare cases, unfortunately even lethal, of myocarditis and pericarditis. And a few days after the publication of updated data as of July 3 from the EudraVigilance pharmacovigilance platform on adverse reactions in EU countries that have registered more than 17,000 deaths after one or two doses of the four EMA authorized vaccines.
PIU’ DI 17MILA MORTI DOPO I VACCINI COVID NEI PAESI UE. Il 49 % di 837mila Reazioni Avverse sono Gravi!
Among these there are also the dramatic statistics on adverse reactions recorded by the EudraVigilance platform which show a limited efficacy of the current vaccines (and in particular of Pfizer): 745 fatal cases in total involving the unknown of 3,876 infected with unknown outcome, that is, it is not known whether they have recovered and died.
In Italy, the case of four nurses, all serving in the hospital of Gela, in the province of Caltanissetta, has caused a sensation, tested positive for covid despite having already had the second dose of vaccine administered in recent months. The four have mild flu symptoms and now the unions Nursind and Uil Fpl are asking to start a screening of workers to measure the level of antibodies.
UE, RADDOPPIA IL NUMERO DI VACCINATI MORTI DI COVID. 745 Casi Fatali (479 dopo Pfizer) su 9mila Contagiati. E di 3.876 non si sa la Sorte!
Israel, on the other hand, has just stated that it has seen the effectiveness of the Pfizer vaccine drop from 90 to 64% with the spread of the Delta variant. Mikael Dolsten, Pfizer’s scientific director, said that the critical issues that Israel is experiencing with the new infections would be due to infections in people vaccinated in January or February. “There is probably a risk of reinfection because the antibodies go down as expected,” he said.
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Albert Bourla, Pfizer’s chief executive and creator of the RNA vaccine, believes that “people will need a booster dose of Covid-19 vaccine every 12 months and that the company is developing an updated version of the vaccine that takes the entire spike protein of the Delta variant. ‘
«It is understandable that drug companies enthusiastically push for a recall, as it would bring them huge profits. But at the moment there are no supporting data, so the FDA and CDC are right to give, for now, a negative opinion. For the future, let’s be careful and let’s get ready» says virologist Roberto Burioni, professor at the Vita-Salute San Raffaele University in Milan, commenting on Pfizer’s announcement on Twitter.
THE RISK OF VACCINE-RESISTANCE
The risk of a vaccine-resistance had already been announced between February and March by an interview with the Italian molecular biology expert Dr. Loretta Bolgan, published in Gospa News in relation to the dangers of pulmonary immunopathology inherent in vaccines as evidenced by a university research Chinese, and from a prophetic article written by Christie Aschwanden in the authoritative specialist journal Nature.
“We’re moving away from the idea that we’ll hit the herd-immunity threshold and then the pandemic will go away for good,” says epidemiologist Lauren Ancel Meyers, executive director of the University of Texas at Austin COVID-19 Modeling Consortium. This shift reflects the complexities and challenges of the pandemic, and shouldn’t overshadow the fact that vaccination is helping, according to Nature.
«“The vaccine will mean that the virus will start to dissipate on its own,” Meyers says. But as new variants arise and immunity from infections potentially wanes, “we may find ourselves months or a year down the road still battling the threat, and having to deal with future surges”.
Long-term prospects for the pandemic probably include COVID-19 becoming an endemic disease, much like influenza. But in the near term, scientists are contemplating a new normal that does not include herd immunity. Here are some of the reasons behind this mindset, and what they mean for the next year of the pandemic» wrote Aschwanden.
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“Herd immunity is only relevant if we have a transmission-blocking vaccine. If we don’t, then the only way to get herd immunity in the population is to give everyone the vaccine,” says Shweta Bansal, a mathematical biologist at Georgetown University in Washington DC. Vaccine effectiveness for halting transmission needs to be “pretty darn high” for herd immunity to matter, she says, and at the moment, the data aren’t conclusive. “The Moderna and Pfizer data look quite encouraging,” she says, but exactly how well these and other vaccines stop people from transmitting the virus will have big implications.
«Even as vaccine roll-out plans face distribution and allocation hurdles, new variants of SARS-CoV-2 are sprouting up that might be more transmissible and resistant to vaccines. “We’re in a race with the new variants,” says Sara Del Valle, a mathematical and computational epidemiologist at Los Alamos National Laboratory in New Mexico. The longer it takes to stem transmission of the virus, the more time these variants have to emerge and spread, she says» reads on Nature.
«There’s another problem to contend with as immunity grows in a population, Ferrari says. Higher rates of immunity can create selective pressure, which would favour variants that are able to infect people who have been immunized. Vaccinating quickly and thoroughly can prevent a new variant from gaining a foothold. But again, the unevenness of vaccine roll-outs creates a challenge, Ferrari says. “You’ve got a fair bit of immunity, but you still have a fair bit of disease, and you’re stuck in the middle.” Vaccines will almost inevitably create new evolutionary pressures that produce variants, which is a good reason to build infrastructure and processes to monitor for them, he adds» concluded Aschwanden.
THE VARIANTS MAY BE CREATED BY VACCINES
These notable passages of the article are perfectly connected with what has already been reported by Gospa News on the Covid-19 variants thanks to an interview conducted by Professor Francesco Cappello to Dr Loretta Bolgan, who graduated in chemistry and pharmaceutical technologies in Padua, where he earned his PhD in pharmaceutical sciences working as a Research fellow at Massachusetts General Hospital (Boston). She then worked as an industrial researcher in the development of molecular biology diagnostic kits.
With reference to the SARS-Cov-2 virus, Dr. Bolgan specified: «We must consider that single-stranded RNA viruses such as these, not only rapidly form mutants, especially in the part of the Spike which is immunogenic, thus managing to escape quickly to what is the attack of the immune system, especially adaptive. There is, in fact, an RNA-dependent RNA polymerase that introduces many errors in its replication, thus forming, very quickly, mutants with mutations that are present in all the viruses of the new mutant, that is, in all copies, at 100%. However, it can also form a population of minor mutants, present in a percentage ranging from 20 to 80% of the major mutant that are called almost-species».
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«So alongside the major mutant there are also hundreds of these minor mutants, all in competitive equilibrium with each other. When vaccinating, specific antibodies are produced for the vaccine antigen but these antibodies produced through the vaccine are not able to bind to all minor mutants, so the minor mutants that escape the binding to the vaccine antibody are properly those that are they replicate and resist because they have a selective advantage. They are then selected precisely by vaccination and here is the resistance vaccine! And here the famous London variant, as well as those that occurred in France or elsewhere, could have this origin. It’s easy to assume that they were caused by vaccination» added the molecular biology expert.
VACCINES AGAINST A BIO-LAB MANMADE VIRUS
Following the line of the reasoning of Dr. Bolgan but also of the other experts cited by Nature, the suspicion emerges that the immunization campaign is a “dog biting its tail” in a vaccine-resistance spiral similar to the one that in the last decade has alarmed about antibiotics.
Unfortunately, however, the scientific community, largely funded by the Big Pharma vaccines gathered in a “cartel” by Bill Gates on September 30, 2020, seems to want to proceed in the only direction of global immunization, preached by the same NGOs of Gates – that today manage the WHO Covax plan – in very suspicious times during a “prophetic” summit organized by the European Commission in Brussels on 12 September 2019 which saw the participation of a Pfizer manager.
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As evidenced by the complaint for the massacre, presented to hundreds of public prosecutors by the biologist Franco Trinca together with the lawyer Alessandro Fusillo and the army of their “followers”, multiple effective therapies against Covid-19 were and are being ignored to make the guidelines of the Italian government of a “watchful wait with paracetamol”.
These methods of treatment have proved counterproductive for many patients and less effective than other therapies such as Vitamin D and Cortisone, reported by Gospa News on the basis of authoritative medical research but ignored by the Italian Minister of Health Roberto Speranza.
The great unknown about the origins of the SARS-Cov-2 virus is also grafted into this chaos of ignored scientific information, which by now dozens of researchers believe to have been created in the laboratory with the gain of function for the enhancement of the viral load.
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This aspect is far from irrelevant in the fight against the Covid-19 pandemic because the confirmation of an artificial origin can legitimize not only the theory of a laboratory “leak” but also that of an intentional release of a SARS-Cov -2 which has all the characteristics to be defined as a disturbing bacteriological weapon, given the reported presence of HIV inside the SARS pathogen as tested in dozens of researches on chimeric recombinant viruses conducted in “a deal between China and the US” according to professor Luc Montagnier.
If this viral nightmare was really built in the laboratory who can exclude that it has not been calibrated in various genotypes of different lethality, as hypothesized by bio-engineer Pierre Bricage, former NATO consultant?
MASSACRE IN RUSSIA: BY VARIANTS OR BIO-WEAPONS?
Who can exclude that behind the variants are not hidden precisely these different pathogens engineered as bio-genetic weapons, studied by the DTRA agency of the Pentagon in the laboratories of the former Soviet Union (in Georgia and Ukraine) and therefore capable of affecting a certain population-ethnicity compared to another? Until there is the will of governments to clarify / admit the origin of the laboratory SARS-2 virus, known to all intelligence in the world according to an Israeli military intelligence microbiologist, these doubts will remain a huge mystery.
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These spy story hypotheses, in fact, could perhaps explain why the Delta variant in Italy has not caused a significant increase in mortality, although 40% of the inhabitants are not yet vaccinated, while in Russia it is causing a massacre …
“In Russia in the last 24 hours, 752 deaths caused by Covid-19 have been ascertained, the maximum in a single day since the beginning of the epidemic: the Tass reports citing the anticoronavirus operations center. According to official data, in Russia during the last day there were 25,082 new cases of coronavirus, of which 5,694 in Moscow “.
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The lethality rate rose to 2.46% while only 19 million Russians received at least one dose of the vaccine (Sputnik V) in the country against a population of 146 million. Eight regions, therefore, will introduce mandatory vaccination to increase the percentage of vaccinated. But a new nightmare is already on the horizon …
«The World Health Organization has revealed that it has placed a new Covid-19 strain first discovered in Russia on its online list of variants for monitoring. It joins a selection of eleven other unnamed coronavirus mutations. The strain was first detected in January this year, but it has only now been deemed severe enough to be listed» reported Russia Today.
According to the WHO classification system, variants are determined first to be designated for “further monitoring,” before being promoted to “of interest,” and then, finally, “of concern.” If the newly discovered variant found in Russia is determined to be more serious, it will be given a Greek letter name. As of now, it is simply known as AT.1.
Fabio Giuseppe Carlo Carisio
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